Scientists investigated why Ebola virus is so deadly when it spreads from animals to humans and then from human-to-human contact. The research team looked at the Zaire Ebola strain in an animal system to understand how it gains strength. This virus is responsible for the current outbreak in West Africa.
They found that initially the animal systems were not affected by the virus, but subsequent transmission into other animals caused the virus to 'hot up' and become more severe.
The team analysed the viruses at different stages and were able to identify several changes in its genetic material that were associated with increased disease.
Professor Julian Hiscox, who led the study from the University's Institute of Infection and Global Health, explains: "The work tells us that the evolutionary goal of Ebola virus is to become more lethal.
"We were able to show through genetic analysis which parts of the virus are involved in this process. The information we have gathered will now allow us to monitor for such changes in an outbreak as well as develop future treatment strategies."
Professor Roger Hewson, leading the study from Public Health England, Porton Down, said: "Ebola virus is such a devastating infection to the people affected by the disease and the economy of West Africa.
"Our understanding of Ebola virus biology is way behind that of other viruses and our collaboration shows how we can bring together our specialists skills to close this knowledge gap."
Professor Miles Carroll, a co-author of the work, said: "This study has allowed the team to be at the forefront of developing methodologies to analyse patient samples recently taken by the European Mobile Laboratory from West Africa to understand disease evolution during the current outbreak"
Story Source:
The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.
Journal Reference:
Stuart D Dowall, David A Matthews, Isabel García-Dorival, Irene Taylor, John Kenny, Christiane Hertz-Fowler, Neil Hall, Kara Corbin-Lickfett, Cyril Empig, Kyle Schlunegger, John N Barr, Miles W Carroll, Roger Hewson, Julian A Hiscox.Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicity. Genome Biology, 2014; 15 (11) DOI: 10.1186/s13059-014-0540-x
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